Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine

Figure 1 Bradykinin-evoked increase in short-circuit current is mediated through B2R but not B1R. A: Application of BK (10 nM) to the serosal side of the ileal preparation of guinea pigs (P < 0.001); B: Quantitative data showing the effect of B1 and B2 receptor agonists on baseline Isc and the effect of B2 receptor antagonist on BK-evoked Isc. Values are expressed as mean ± SE; n = 6-12 animals. BK: Bradykinin; Isc: Increase in short-circuit current.