Efficacy and tolerability of hydrogen carbonate-rich water for heartburn

Table 2 Overview of the changes with regard to heartburn (full analysis set)

Heartburn (n = 48)	V2mean (SD)median	V5mean (SD)median	V2-V5mean (SD)median	P value	Proportion of patients displaying a decrease/an increase	P value
Frequency	8.06 (4.43)	3.00 (2.29)	5.06 (4.81)	< 0.001	89.6%/8.3%	< 0.001
	8.0	2.5	5.0
Duration (min)	43.7 (55.9)	24.7 (32.2)	19.0 (40.7)	0.002	79.2%/20.8%	< 0.001
	24.5	12.7	4.2