Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine

Table 4 Digestive enzymes and peptidases altered in small intestine of Nkcc1^-/- mice

Gene symbol	Description	Average intensity	Fold change	P-value
Cpa1	Carboxypeptidase A1, pancreatic	1811	15.86	0.00001
Elane	Elastase 2	2118	12.05	0.00001
Try4	Trypsin 4	2251	9.91	0.00001
Cpb1	Carboxypeptidase B1 (tissue)	866	9.15	0.00001
Try10	Trypsin 10	2306	8.33	0.00001
Ctrc	Chymotrypsin C (caldecrin)	397	7.79	0.0003
Ctrb1	Chymotrypsinogen B	3360	7.66	0.00001
Pnlip	Pancreatic lipase	1938	7.24	0.00001
Prss1	Protease, serine 1 (trypsin 1)	1481	6.93	0.00001
Cel	Carboxyester lipase, pancreatic	356	6.73	0.00001
Cela3b	Elastase 3B, pancreatic	1576	6.69	0.00001
Prss2	Trypsin II, anionic	716	6.52	0.0001
Pnliprp1	Pancreatic lipase related protein 1	574	5.83	0.0001
Cela1	Elastase 1, pancreatic	549	4.84	0.0002
2210010C04Rik	RIKEN cDNA 2210010C04 gene	125	3.89	0.0005
Ctrl	Chymotrypsin like; chymotrypsin A	1431	3.49	0.0030
Klk1	Kallikrein 1	278	1.82	0.0180
Klk1b26	Kallikrein 1-related petidase b26	988	1.80	0.0030
Pnliprp2	Pancreatic lipase related protein 2	833	1.74	0.0181
Klk1b21	Kallikrein 21	386	1.66	0.0036
Cyp7b1	Cytochrome P450 7B1	100	1.53	0.0229
Prcp	Prolyl carboxypeptidase (angiotensinase C)	566	1.51	0.0047
Amz1	Archaelysin family metallopeptidase 1	887	1.35	0.0121
Otud4	OTU domain containing 4	524	-1.34	0.0221
Pga5	Pepsinogen 5, group I	168	-1.42	0.0198
Dpep3	Dipeptidase 3	301	-1.48	0.0197
Hpn	Serine protease hepsin	206	-1.99	0.0211

Differential expression is presented as fold-changes in Nkcc1^-/- intestine relative to wild-type intestine. Average intensity (average of Cy3 and Cy5 fluorescence intensities) is roughly indicative of relative expression levels. P values are less than or equal to the numbers shown.