Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disorders

Figure 1 Proposed algorithm for treatment management of inflammatory bowel disease patients who are either Epstein-Barr virus seropositive or negative. ¹EBV monospot or EBV IgM have not been shown to be helpful in in determining serostatus; ²EBV viral load should be done by polymerase chain reaction in whole blood in EDTA collection tube. EBV: Epstein-Barr virus; IBD: Inflammatory bowel disease; EBNA: Epstein-Barr virus-determined nuclear antigen; LPD: Lymphoproliferative disorders; VCA: Viral-capsid antigen; EDTA: Ethylenediaminetetraacetic acid.