Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma

Figure 2 Effects of the adipokines leptin and adiponectin on Barrett’s esophagus and esophageal adenocarcinoma. Obesity, more specifically visceral obesity, is associated with increased serum leptin and decreased serum adiponectin levels. Leptin and adiponectin have a set of antagonistic pathophysiological actions on Barrett’s esophageal and adenocarcinoma cells.