Contemporary review of drug-induced pancreatitis: A different perspective

Table 1 Classification system of drug-induced acute pancreatitis according to Badalov et al[11]

	Definition	Example
Class I drug	Ia: at least one case report, evidence of a positive re-challenge, and exclusion of other causes of AP	Codeine, cytarabine, dapsone, enalapril, furosemide, isoniazid, mesalamine, metronidazole, pentamidine, pravastatin, procainamide, simvastatin, sulfamethoxazole, sulindac, tetracycline, valproic acid
	Ib: similar to class Ia, except that other causes of AP could not be ruled out	Amiodarone, azathioprine, dexamethasone, ifosfaide, lamivudine, losartan, 6-MP, premarin, TMP-SMZ
Class II drugs	Include at least four case reports with a consistent latency period for at least 75% of the cases	Acetaminophen, Clozapine, DDI, erythromycin, estrogen, l-asparaginase, propofol, tamoxifen
Class III drug	At least two case reports but do not have re-challenge data or a consistent latency period	Alendronate, carbamazepine, ceftriaxone, clarithromycin, cyclosporin, hydrochlorothiazide, interferone/ribavirin, metformin, minocycline, naproxen, paclitaxel, prednisone, prednisolone
Class IV drug	One case report without re-challenge data	Ampicillin, cisplatin, colchicine, cyclophosphamide, diclofenac, doxorubicin, interleukin-2, octreotide, propoxyphene, rifampin, risperidone, sertaline, tacrolimus, vincristine

AP: Acute pancreatitis; 6-MP: 6-mercaptopurine; TMP-SMZ: Trimethoprim and sulfamethoxazole.