Perihilar cholangiocarcinoma: Current therapy

Table 4 Surgery performed according to the time period[51] n (%)

		Time period
	Total	Earlier period		Later period		P
		1997-1990	1991-2000	2001-2005	2006-2010
Number of patients resected	574	72	116	168	218
Resectability	574/754 (76.1)	72/93 (77.4)	116/148 (78.4)	168/216 (77.8)	218/297 (73.4)	0.406
Type of hepatectomy1						< 0.001
S1,4,5,6,7,8	43 (7.5)	5 (6.9)	11 (9.5)	4 (2.4)	23 (10.6)
S1,5,6,7,8	177 (30.8)	17 (23.6)	40 (34.5)	53 (31.5)	67 (30.7)
S1,2,3,4,5,8,	110 (19.2)	4 (5.6)	12 (10.3)	29 (17.3)	65 (29.8)
S1,2,3,4	187 (32.6)	27 (37.5)	35 (30.2)	68 (40.5)	57 (26.1)
S1,4,5,8/S1,5,8/S1,4/S1	38 (6.6)	13 (18.1)	10 (8.6)	11 (6.5)	4 (1.8)
Without hepatectomy	19 (3.3)	6 (8.3)	8 (6.9)	3 (1.8)	2 (0.9)
Combined resection
Pancreatoduodenectomy	74 (12.9)	9 (12.5)	13 (11.2)	20 (11.9)	32 (14.7)	0.553
Portal vein resection	206 (35.9)	23 (31.9)	36 (31.0)	58 (34.5)	89 (40.8)	0.116
Wedge resection	36	15	6	10	5
Segmental resection	170	8	30	48	84
Hepatic artery resection	76 (13.2)	0	5 (4.3)	25 (14.9)	46 (21.1)	< 0.001
Operative time, min2	668 ± 134	664 ± 162	787 ± 170	675 ± 145	605 ± 134	< 0.001
Blood loss, mL2	2491 ± 2156	4414 ± 2791	3773 ± 3024	1898 ± 1268	1768 ± 1130	< 0.001
Homologous blood transfusion	271 (47.2)	68 (94.4)	93 (80.2)	46 (27.4)	64 (29.4)	< 0.001

Homologous blood includes packed red blood cell and fresh-frozen plasma. Note that P indicates the statistical difference between the earlier period (1977-2000) and the later period (2001-2010).

¹Expressed as Couinaud’s hepatic segments resected;

²Excluding 19 patients who did not undergo hepatectomy.