Similarities and differences between Behçet's disease and Crohn's disease

Table 1 Diagnostic criteria for Behçet’s disease and Crohn’s disease

	International Study Group Diagnostic Criteria for Behçet’s disease[70]	Proposed diagnostic criteria for Crohn’s disease
		Japan Criteria[72]	Lennard-Jones Criteria[73]	Copenhagen Criteria[8]
Major findings	Recurrent oral ulcerations	A: Longitudinal ulcer B: Cobblestone-like appearance C: Noncaseating epithelioid cell granuloma	Typical diarrhea history for at least 2 mo; 1 Radiological features of CD: segmental distribution, deep ulcerations or cobblestone pattern, thickened bowel wall, coarse mucosal relief, stenotic segments and fistulae; 2 Macroscopic diagnosis by endoscopy: patchy penetrating lesions, fissuring and strictures 3 Fistulas and/or abscesses with typical intestinal disease	1 History of abdominal pain, weight loss and/or diarrhea for more than 3 mo 2 Characteristic endoscopic findings of ulceration (aphtous lesions, snail track ulceration) or cobble stoning or radiological features of stricture or cobble stoning 3 Histopathology consistent with Crohn’s disease (epitheloid granuloma of Langerhans type or transmural discontinuous focal or patchy inflammation) 4 Fistula and/or abscess in relation to affected bowel segments
Minor findings	Recurrent genital ulcerations Eye lesions Skin lesions Positive pathergy test	(1) Irregular-shaped and/or quasi-circular ulcers or aphthous ulcerations found extensively in the gastrointestinal tract (2) Characteristic perianal lesions (3) Characteristic gastric and/or duodenal lesions
Definite	Major finding plus two minor findings	1 Major finding A or B 2 Major finding C, with minor finding (1) or (2) 3 All minor findings (1), (2), and (3)	Positive findings or one positive plus the finding of granuloma	At least two of the criteria present