Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma

Table 6 Pathobiological studies of intrahepatic cholangiocarcinoma 3

Source	n	Method	Target	Conclusion
Li et al[56]	-	Tissues	miR-214	(-)increased expression of Twist(EMT
				-associated gene)
Gu et al[57]	123	IHC	IL-17cells	(+)poor prognosis
			(intratumoral)
Higashi et al[58]	63	IHC	MUC16	(+)poor prognosis
Gu et al[59]	83	IHC	E-cadherin	(-)poor prognosis
			Beta-catenin	(-)V
			EGFR	(+)Por
Wang et al[60]	77	IHC	P-70S6K	(+)Por
			4EBP1	(+)poor prognosis
Hirashita et al[61]	35	IHC	MMP-7	(+)poor prognosis
Srimunta et al[62]	55	IHC	ABCC-1	(+)poor prognosis
Morine et al[63]	35	IHC	HDAC	(+)advanced stage, LN
				poor prognosis
Wakai et al[64]	34	IHC	RRM1	(+)gemcitabine resistance
Larbcharoensub et al[65]	60	IHC	ABCG2	(-)poor prognosis, LN, Por
Lee et al[66]	101	IHC	PTEN	(+)favorable prognosis
			P-AKT1	(+)favorable prognosis
			P-MTOR	(+)favorable prognosis
Dong et al[67]	108	IHC	Beclin1	(-)LN, poor prognosis
Shinozaki et al[68]	83	IHC	Claudin-18	(+)LN, PI-type, perineural invasion
Wakai et al[69]	34	IHC	NQO1	(-)Por, poor prognosis
Aishima et al[70]	110	IHC	S100P	(+)PI-type
			S100P(nuc)	(+)LN, V
Zhou et al[71]	89	IHC	MAGE3/4	(+)larger tumor size, poor prognosis

EGFR: Epidermal growth factor receptor; P-70S6K: P70 ribosomal protein S6 kinase; 4EBP1: 4E-binding protein-1; ABCC-1: Adenosine triphosphate binding cassette C1; HDAC: Histone deacetylase; RRM1: Ribonucleotide reductase-M1; ABCG2: Adenosine 5’ triphosphate-binding cassetteG2; PTEN: Phosphatase and tensin homolog on chromosome ten; PAKT: Phosphorylated Akt; PMTOR: Phosphorylated MTOR; NQO1: Quinine oxidoredactase; MAGE: Melanoma antigen.