Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma

Table 2 Clinical studies of intrahepatic cholangiocarcinoma focused on the macroscopic subtypes

Ref.	n	Findings or conclusion
Uchiyama et al[15]	334	Lymph node metastasis: MF: 16%; IG: 0%; PI and MF + PI: 60%
		Survival rate (5 yr): MF: 26%; IG: 79.3%; PI and MF + PI: 19.4%
Uno et al[17]	273	Rate of PI-type: 7.9%
		The PI-type shows significantly better survival than MF- and MF + PI-type.
Morine et al[18]	22	The PI-type shows a lower incidence of intrahepatic metastasis
		Routine lymph node dissection do not improve survival in MF-type

MF: Mass-forming type; IG: Intraductal growth type; PI: Periductal infiltrative type