Review of the diagnosis, classification and management of autoimmune pancreatitis

Table 1 The Mayo clinic HISORt criteria for the diagnosis of autoimmune pancreatitis

Category	Criteria
Histology	One of the following:
	Periductal lymphoplasmacytic infiltrate with obliterative phlebitis and storiform fibrosis (LPSP)
	Lymphoplasmacytic infiltrate with storiform fibrosis showing abundant IgG4 positive cells (> 10 cells/HPF)
Imaging (CT)/(MRI)	Typical; diffusely enlarged gland with diffuse rim enhancement, diffusely irregular attenuated pancreatic duct
	Other; focal pancreatic mass or enlargement; focal pancreatic duct stricture; pancreatic duct stricture, pancreatic atrophy; pancreatic calcification or pancreatitis
Serology	Elevated serum IgG4 level
Other organ involvement	Hilar/intrahepatic biliary strictures, persistent distal biliary strictures, parotid or lacrimal gland involvement, mediastinal lymphadenopathy or retroperitoneal fibrosis
Response to steroid therapy	Resolution/Marked improvement of pancreatic or extrapancreatic manifestion with steroid therapy

LPSP: Lymphoplasmacytic sclerosing pancreatitis; CT: Computed tomography; MRI: Magnetic resonance imaging; IgG4: Immunoglobulin G4; HPF: High powered field.