Genetic contribution to motility disorders of the upper gastrointestinal tract

doi:10.4291/wjgp.v4.i4.65

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Nov 15, 2013; 4(4): 65-73
Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.65

Table 1 Overview of genetic association studies in achalasia

Protein (gene)	Polymorphism	Finding	Ref.
PTPN22	C1858T	Risk factor	[28]
IL-10	GCC	Protective	[29]
IL-23R	G381A	Protective	[30]
iNOS	iNOS22*A/A	No association	[35]
eNOS	eNOS*4°4°	No association	[35]
iNOS	(CCTTT) n > 12	Risk factor	[36]
cKit	Rs6554199	Risk factor	[37]
VIPR type 1	Rs437876 and rs896	Risk factor	[38]

iNOS: Inducible nitric oxide synthase; IL: Interleukin; PTPN22: Polymorphism C1858T of phosphatase N22.

Citation: Sarnelli G, D’Alessandro A, Pesce M, Palumbo I, Cuomo R. Genetic contribution to motility disorders of the upper gastrointestinal tract. World J Gastrointest Pathophysiol 2013; 4(4): 65-73
URL: https://www.wjgnet.com/2150-5330/full/v4/i4/65.htm
DOI: https://dx.doi.org/10.4291/wjgp.v4.i4.65