Duodenal epithelial transport in functional dyspepsia: Role of serotonin

Figure 2 Dose-response of 5-hydroxytryptamine-induced short circuit current. Addition of 5-hydroxytryptamine (5-HT) in cumulative concentrations by steps of a factor three from 3 to 243 μmol/L on the serosal side of duodenal biopsies mounted in an Ussing chamber resulted in an increased short circuit (μA/cm²), in both functional dyspepsia patients (n = 8) and healthy controls (n = 9), with significantly lower values in the dyspeptic group (P < 0.001 for the overall difference) (mean ± SE). SCC: Short circuit current.