Regulation of colon cancer recurrence and development of therapeutic strategies

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Feb 15, 2012 (publication date) through Feb 7, 2025

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Feb 15, 2012; 3(1): 1-9
Published online Feb 15, 2012. doi: 10.4291/wjgp.v3.i1.1

Table 2 Major natural compounds targeting Wnt/β-catenin pathway undergoing clinical trials for the treatment of colon cancer

Category	Compound	Target	Mechanism	Clinical trials
Category	Compound	Target	Mechanism	identification No.
Vitamins	Retinoids/vitamin-A	Beta-catenin	Compete with TCFs, production of inhibitory protein-disabled-2	NCT00270647, NCT00712647
	Vitamin-D	Beta-catenin	Production of inhibitory proteins-dickkopf-1 and 4	NCT00208793, NCT00870961, NCT01198548, NCT00399607, NCT01150877, NCT00585637
	Vitamin-E	Unknown	Unknown	NCT00706121, NCT00270647
	Pyridoxine	Unknown	Unknown	NCT00559858
Polyphenols	Quercetin	Wnt/beta-catenin	Unknown	NCT00003365
	Epigallocatechin-3-gallate from green tea	Wnt/beta-catenin	Plieotropic	NCT01239095, NCT00718094
	Curcumin	Wnt/beta-catenin	Plieotropic	NCT00365209, NCT00295035, NCT00027495, NCT00973869, NCT00745134, NCT00118989, NCT00927485, NCT00641147
	Resveratrol	Wnt/beta-catenin	Unknown	NCT00256334, NCT00578396, NCT00433576, NCT00920803
	Dictyostelium discoidem	Wnt/beta-catenin	Activation of GSK-3beta by differentiation inducing factors-1,3	No current trails
Lipids	Omega 3 fatty acids and n-3 polyunsaturated fatty acids	Mitochondrial membrane of tumor cells	Enhanced reactive oxygen species generation and decreased cell anti-oxidant capacity leading to apoptosis in tumor cells	NCT01127867, NCT00145015, NCT01218841, NCT00432913, NCT00488904, NCT00168987, NCT00510692, NCT01070355, NCT01048463

ID numbers source: clinicaltrails.gov.

Citation: Kanwar SS, Poolla A, Majumdar AP. Regulation of colon cancer recurrence and development of therapeutic strategies. World J Gastrointest Pathophysiol 2012; 3(1): 1-9
URL: https://www.wjgnet.com/2150-5330/full/v3/i1/1.htm
DOI: https://dx.doi.org/10.4291/wjgp.v3.i1.1