Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

Table 3 Histological follow-up studies of gastric intraepithelial neoplasia through mild to severe dysplasia

Reports (yr)	LGIN (including mild to moderate dysplasia)		HGIN (including severe dysplasia)
	Detection of carcinoma n (%)	Interval (mean) n (%)	Detection of carcinoma	Interval (mean)
Saraga et al[49], 1987	1/64 (2)	4 yr	17/21 (81)	4 mo
Lansdown et al[46], 1990	0/7 (0)	-	11/13 (85)	5 mo
Rugge et al[50], 1991	12/69 (17)	1 yr	6/8 (75)	4 mo
Fertitta et al[51], 1993	7/30 (23)	10 mo	25/31 (81)	5 mo
Farinati et al[52], 1993	-	-	16/49 (33)1	-
Di Gregorio et al[53], 1993	6/89 (7)	2 yr	6/10 (60)	11 mo
Bearzi et al[54], 1994	8/81 (9.9)	-	27/44 (61)	-
Rugge et al[55], 1994	13/90 (14)	2 yr	14/18 (78)	9 mo
Kolodziejczyk et al[56], 1994	2/351 (5.72)	-	7/7 (100)	-
Kokkola et al[57], 1996	0/9 (0)	-	2/3 (67)	1.5 yr
Rugge et al[19], 2003	8/90 (8.9)	4 yr	11/16 (69)	34 mo
Yamada et al[58], 2004	0/38 (0)	-	1/10 (10)	54 mo
Park et al[59], 2008	3/26 (12)	58 mo3	1/1 (100)	58 mo3
Overall	60/628 (9.5)		145/231 (63)

Proportion progressing to carcinoma and mean interval.

¹Moderate or severe;

²Mild or moderate dysplasia;

³Overall follow-up interval. LGIN: Low-grade intraepithelial neoplasia; IN: Intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia.