Gene and cell therapy based treatment strategies for inflammatory bowel diseases

doi:10.4291/wjgp.v2.i6.114

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Dec 15, 2011 (publication date) through Jul 18, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Dec 15, 2011; 2(6): 114-122
Published online Dec 15, 2011. doi: 10.4291/wjgp.v2.i6.114

Table 3 Overview of the combined gene and cell therapy based treatment strategies for inflammatory bowel diseases as discussed in this review

	Applied strategy	Viral vector used	Reference for viral vector used	Status of development	Reference for status of development
Combined gene and cell therapy	Ex vivo generated Treg/Tr1	Retrovirus	[113,115]	Preclinical	[113,115]
Combined gene and cell therapy	T cell receptor transgenic Treg	Retrovirus	[116]	Preclinical	[116]

The status of development refers to research which has already been performed. Treg: CD4⁺CD25^highFOXP3⁺ regulatory T cell; Tr1: Type 1 regulatory T cell.

Citation: Marel SVD, Majowicz A, Deventer SV, Petry H, Hommes DW, Ferreira V. Gene and cell therapy based treatment strategies for inflammatory bowel diseases. World J Gastrointest Pathophysiol 2011; 2(6): 114-122
URL: https://www.wjgnet.com/2150-5330/full/v2/i6/114.htm
DOI: https://dx.doi.org/10.4291/wjgp.v2.i6.114