Link between irritable bowel syndrome, depression, and colorectal cancer risk in young patients: Age-matched nationwide population-based study

Table 2 Prevalence and risk of colorectal cancer in age matched (1:1) young (18-44 years) depressed irritable bowel syndrome + vs irritable bowel syndrome-cohort 2019

	IBS- (n = 14370)	IBS+ (n = 14370)	P value
Rate of CRC	0.2%	0.2%	0.196
Logistic regression models	Odds ratio	95%CI (LL-UL)	Adjusted P value
Model 1-Univariate	0.71	0.23-2.25	0.565
Model 2-Adjusted for baseline sociodemographic characteristics + hospital characteristics	0.73	0.22-2.41	0.610
Model 31-Model 2 + relevant preexisting comorbidities	0.89	0.21-3.83	0.871

¹Adjusted for baseline sociodemographic and hospital characteristics like age, sex, race, median household income quartile, hospital location/teaching status, region, acquired immunodeficiency syndrome, drug abuse, alcohol abuse, tobacco use disorder, anxiety, bipolar disorder, borderline personality disorder, and psychoses, arthropathies, hypertension, diabetes, hyperlipidemia, obesity, peripheral vascular disease, prior myocardial infarction, and cancer.

IBS: Irritable bowel syndrome; CRC: Colorectal cancer.