Link between irritable bowel syndrome, depression, and colorectal cancer risk in young patients: Age-matched nationwide population-based study

Table 1 Age matched (1:1) young (18-44 years) depressed cohort with vs without irritable bowel syndrome, 2019

Variables	Total young admissions with depression, n (%)		P value
	IBS- (n = 14370)	IBS+ (n = 14370)
Age (years) at admission	36 (29-41)	36 (29-41)	1
Median (IQR)
Sex
Male	34.20	16.10	< 0.001
Female	65.80	83.90
Race
White	67.00	80.80	< 0.001
Black	16.10	11.00
Hispanic	11.40	5.60
Asian or Pacific Islander	1.40	0.60
Native American	1.00	0.40
Others	3.20	1.70
Median household income national quartile for patient ZIP Code
0-25th	32.00	25.90	< 0.001
26-50th	26.10	25.70
51-75th	24.00	27.30
76-100th	17.90	21.10
Primary expected payer
Medicare	13.90	15.00	< 0.001
Medicaid	40.10	31.20
Private including HMO	34.60	45.40
Location/teaching status of hospital
Rural	7.70	7.40	0.029
Urban non-teaching	14.90	16.00
Urban teaching	77.50	76.60
Comorbidities
Acquired immune deficiency syndrome	1.00	0.40	< 0.001
Arthropathies	3.90	6.20	< 0.001
Dementia	0.30	0.10	0.001
Hypertension, complicated	7.90	6.40	< 0.001
Hypertension, uncomplicated	21.30	23.00	0.001
Diabetes with chronic complications	9.70	9.70	1
Diabetes without chronic complications	6.50	6.90	0.193
Hyperlipidemia	12.00	14.60	< 0.001
Obesity	23.60	27.70	< 0.001
Peripheral vascular disease	1.30	1.60	0.014
Prior MI	1.70	0.70	< 0.001
Chronic pulmonary disease	16.30	26.10	< 0.001
Hypothyroidism	7.80	11.20	< 0.001
Other thyroid disorders	1.10	2.00	< 0.001
Prior TIA/Stroke without Neurologic deficit	2.10	2.50	0.017
Prior VTE	5.00	5.80	0.002
Cancer	2.20	2.00	0.409
Anxiety and fear related disorders	54.60	68.60	< 0.001
Psychoses	4.20	4.50	0.312
Bipolar disorder	0.70	1.50	< 0.001
Borderline personality disorder	1.90	2.90	< 0.001
Alcohol abuse	12.00	6.30	< 0.001
Tobacco use disorder	32.80	26.10	< 0.001
Drug abuse	17.80	11.20	< 0.001

IBS: Irritable bowel syndrome; MI: Myocardial infarction; TIA: Transient ischemic attack; VTE: Venous thromboembolism.