Changes in the terminology and diagnostic criteria of non-alcoholic fatty liver disease: Implications and opportunities

Figure 6 Algorithmic approach to the categorization of steatotic liver disease. In the presence of hepatic steatosis either on imaging or liver biopsy, the presence of any of a cardiometabolic risk factor (CMRF) will lead to a diagnosis of metabolic dysfunction-associated steatotic liver disease (SLD) in the absence of other causes of hepatic steatosis. If additional causes of steatosis are identified, then this will qualify for a combination etiology. In the case of alcohol, this is labeled MetALD. In the absence of overt CMRF, other causes must be excluded and if none is identified, this is labeled cryptogenic SLD. MASLD: Metabolic dysfunction-associated SLD; MetALD: MASLD, and moderate alcohol intake.