Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma

Table 3 Multivariate analysis including parameters associated with prognosis in the Log-rank test in the entire group and tumors of the intestinal subtype

Parameters	All group			P value	Intestinal tumors			P value
	HR	Lower (95%CI)	Upper (95%CI)		HR	Lower (95%CI)	Upper (95%CI)
ITB	2.06	1.40	3.01	< 0.001	3.32	2.34	4.72	< 0.001
PTB	1.83	1.29	2.59	< 0.001	2.01	1.32	3.05	< 0.001
LNM	1.53	1.00	2.33	0.04	1.09	0.59	2.04	0.760
Stage	1.06	0.81	1.40	0.63	1.12	0.80	1.58	0.480
Subtype	0.76	0.50	1.17	0.22	-	-	-	-
DR	1.11	0.87	1.42	0.39	1.17	0.86	1.60	0.290

HR: Hazard ratio; CI: Confidence interval; LNM: Lymph node metastasis; PTB: Peritumoral budding; ITB: Intratumoral budding; DR: Desmoplastic reaction; TILs: Tumor infiltrating lymphocytes.