Copyright
©The Author(s) 2023.
World J Gastrointest Pathophysiol. Jun 1, 2023; 14(3): 46-70
Published online Jun 1, 2023. doi: 10.4291/wjgp.v14.i3.46
Published online Jun 1, 2023. doi: 10.4291/wjgp.v14.i3.46
Figure 1 Etiological factors of hepatocellular carcinoma.
Aflatoxin B1, vinyl chloride, smoking, ethanol, and many such factors leads to the development of hepatocellular carcinoma (HCC). Genetic predisposition, hemochromatosis and metabolic genotypes could also be the reason for the initiation of the HCC. There are many stages in the development of HCC including formation of pre-neoplastic lesion and malignant tumour (Created with BioRender.com). IGF: Insulin-like growth factor; TGF-α: Tumour growth factor-α; TGF-β: Tumour growth factor-β.
- Citation: Choudhary HB, Mandlik SK, Mandlik DS. Role of p53 suppression in the pathogenesis of hepatocellular carcinoma. World J Gastrointest Pathophysiol 2023; 14(3): 46-70
- URL: https://www.wjgnet.com/2150-5330/full/v14/i3/46.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v14.i3.46