Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand

doi:10.4291/wjgp.v14.i2.21

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Mar 22, 2023 (publication date) through Apr 3, 2025

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Mar 22, 2023; 14(2): 21-33
Published online Mar 22, 2023. doi: 10.4291/wjgp.v14.i2.21

Table 5 Risk of cholangiocarcinoma due to the combination of polymorphisms of GSTT1 and CYP2E1: Matched case-control study, Ubon Ratchathani, Thailand

*CYP2E1*	*GSTT1* wild		*GSTT1* null		*CYP2E1*	*GSTT1* wild				*GSTT1* null
	Number		Number			Odds ratio¹	95%CI		P value	Odds ratio¹	95%CI		P value	P for interaction
	Case	Control	Case	Control		Odds ratio¹	LL	UL	P value	Odds ratio¹	LL	UL	P value	P for interaction
c1/c1	49	59	25	18	c1/c1	1.00	Reference			2.04	0.95	4.39	0.07	< 0.01
c1/c2 + c2/c2	24	9	5	11	c1/c2 + c2/c2	3.33	1.23	9.00	0.02	0.54	0.14	2.13	0.38	< 0.01

¹Based on the conditional logistic regression model.

CCA: Cholangiocarcinoma; CI: Confidence interval; LL: Lower limit; UL: Upper limit.

Citation: You G, Zeng L, Tanaka H, Ohta E, Fujii T, Ohshima K, Tanaka M, Hamajima N, Viwatthanasittiphong C, Muangphot M, Chenvidhya D, Jedpiyawongse A, Sripa B, Miwa M, Honjo S. Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand. World J Gastrointest Pathophysiol 2023; 14(2): 21-33
URL: https://www.wjgnet.com/2150-5330/full/v14/i2/21.htm
DOI: https://dx.doi.org/10.4291/wjgp.v14.i2.21