Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand

Table 4 Relationship between polymorphisms of drug-metabolizing and inflammation-related enzyme genes and cholangiocarcinoma risk, Ubon Ratchathani, Thailand

Gene	Number of pairs according to gene polymorphism of case and control					Polymorphism	Crude OR	95%CI		P value	Adjusted1 OR	95%CI		P value	Adjusted2 OR	95%CI		P value
								LL	UL			LL	UL			LL	UL
GSTM1
			Case
			Wild	Null
	Control	Wild	8	18		Wild	1.00	Reference			1.00	Reference			1.00	Reference
		Null	18	51		Null	1.00	0.52	1.92	1.000	0.67	0.29	1.56	0.357	0.81	0.37	1.75	0.594
GSTT1
			Case
			Wild	Null
	Control	Wild	44	23		Wild	1.00	Reference			1.00	Reference			1.00	Reference
		Null	21	7		Null	1.10	0.61	1.98	0.763	0.94	0.44	1.98	0.865	1.02	0.52	2.02	0.957
CYP2E1
			Case
			c1/c1	c1/c2	c2/c2
	Control	c1/c1	56	14	4	c1/c1	1.00	Reference			1.00	Reference			1.00	Reference
		c1/c2	12	4	2	c1/c2	1.11	0.52	2.38	0.782	1.02	0.39	2.70	0.966	1.14	0.47	2.77	0.773
		c2/c2	1	0	0	c2/c2	6.19	0.74	52.08	0.093	2.02	0.20	20.67	0.552	4.17	0.45	38.24	0.207
						c1/c2 or c2/c2	1.38	0.68	2.83	0.371	1.14	0.47	2.77	0.767	1.35	0.58	3.11	0.484
IL-6
			Case			-174
			G/G	G/C	C/C
	Control	G/G	90	0	0	G/G	1.00	Reference			1.00	Reference			1.00	Reference
		G/C	1	0	0	G/C	0.00	-	-	-	0.003	0.00	-	0.995	0.0037	0.00	-	0.999
		C/C	0	0	0	C/C	-	-	-	-	-	-	-	-	-	-	-	-
IL-6						-634
			Case
			G/G	G/C	C/C
	Control	G/G	0	4	5	G/G	1.00	Reference			1.00	Reference			1.00	Reference
		G/C	2	13	12	G/C	1.93	0.63	5.93	0.252	1.90	0.49	7.30	0.351	1.69	0.46	6.25	0.432
		C/C	4	18	34	C/C	1.28	0.44	3.73	0.654	1.38	0.40	4.71	0.607	1.45	0.43	4.87	0.551
						G/C or C/C	1.50	0.53	4.21	0.442	1.53	0.46	5.05	0.488	1.52	0.46	4.98	0.489
IL-10						-819 T/C
			Case
			T/T	T/C	C/C
	Control	T/T	23	15	6	T/T	1.00	Reference			1.00	Reference			1.00	Reference
		T/C	15	17	4	T/C	0.81	0.41	1.60	0.537	0.66	0.27	1.63	0.371	0.75	0.34	1.70	0.497
		C/C	8	0	3	C/C	1.19	0.46	3.06	0.715	1.59	0.43	5.93	0.487	1.63	0.51	5.17	0.405
						T/C or C/C	0.91	0.51	1.65	0.763	0.85	0.39	1.87	0.686	0.95	0.47	1.93	0.891
NF-kB						-94 ins/del ATTG
			Case
			del/del	ins/del	ins/ins
	Control	del/del	3	5	3	del/del	1.00	Reference			1.00	Reference			1.00	Reference
		ins/del	4	16	13	ins/del	0.83	0.32	2.17	0.711	1.11	0.27	4.61	0.884	0.79	0.24	2.67	0.708
		ins/ins	9	20	19	ins/ins	0.48	0.19	1.23	0.128	0.32	0.08	1.20	0.090	0.33	0.10	1.03	0.057
						ins/del or ins/ins	0.91	0.51	1.65	0.763	0.49	0.14	1.69	0.258	0.47	0.16	1.38	0.167

¹Adjusted for alcohol consumption and smoking.

²Adjusted for alcohol consumption and smoking. Missing values for these variables were imputed.

CCA: Cholangiocarcinoma; LL: Lower limit; UL: Upper limit.