Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian

Table 4 Association of the single nucleotide polymorphisms in protein tyrosine phosphate non-receptor type 2 gene with patient and disease characteristics

Characteristic		rs7234029			rs2542151
		Variant (n=38, GG or GA)	Wild type (n=70, AA)	P value	Variant (n=44, GG or GT)	Wild type (n=57, TT)	P value
Sex	Female	37%	63%	0.74	38.1%	61.9%	0.46
	Male	33.9%	66.1%		47.5%	52.5%
Age at onset of illness (yr)	Up to 40 yr	39%	61%	0.21	43.4%	56.6%	0.96
	> 40	23.1%	76.9%		44%	56%
Disease behaviour	NSNP	29.6%	70.4%	0.42	45%	55%	0.98
	SP	39.1%	60.9%		42.6%	57.4%
Disease location	Ileal	34.7%	65.3%	0.98	42.9%	57.1%	0.28
	Colonic	35.3%	64.7%		23.5%	76.5%
	Ileocolonic	36.6%	63.4%		43.9%	56.1%
Perianal disease	Present	46.7%	53.3%	0.32	46.7%	53.3%	0.79
	Absent	33.3%	66.7%		43%	57%
Surgery for Crohn’s disease	Yes	32.4%	67.6%	0.67	29.4%	70.6%	0.07
	No	36.6%	63.4%		50.1%	49.9%
Smoking	Yes	25%	75%	0.43	41.7%	58.3%	0.89
	No	36.5%	63.5%		43.8%	56.2%
EIM	Yes	40%	60%	0.62	29.4%	70.6%	0.31
	No	34.1%	65.9%		46.4%	53.6%

SNP: Single nucleotide polymorphism; PTPN2: Protein tyrosine phosphate non-receptor type 2; NSNP: Non-stricturing and non-penetrating; SP: Stricturing and/or penetrating; EIM: Extraintestinal manifestations.