Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance

Figure 1 Effect of bile duct ligation on pharmacokinetics of digoxin in rats. A: Pre-surgery digoxin pharmacokinetic studies was compared and presented as digoxin concentration-versus-time line curves; B: Post-surgery digoxin pharmacokinetic studies were compared and presented as digoxin concentration-versus-time line curves, C: Area under the curve, the area under the digoxin plasma concentration-versus-time. Values are expressed as means ± SD, n = 6; ^aP < 0.05 vs pre-surgery bile duct ligation group, ^bP < 0.05 vs post-surgery sham. BDL: Bile duct ligation; AUC: Area under the curve.