Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance

doi:10.4291/wjgp.v13.i3.73

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May 22, 2022 (publication date) through Jul 27, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. May 22, 2022; 13(3): 73-84
Published online May 22, 2022. doi: 10.4291/wjgp.v13.i3.73

Table 3 Summary of the regulations of cell membrane transporters and potential effects on digoxin clearance

	Efflux	Influx	Effects
Kidney	MDR1: Up-regulated	OATP4C1: Up-regulated	Increase tubule exclusion
Intestine	MDR1: Down-regulated	OATP1A4: Down-regulated	Decrease intestinal absorption
Liver	MDR1: Up-regulated	OATP4C1: Up-regulated	Increase exclusion into bile duct

OATP: Organic anion transporting polypeptides; MDR1: Multidrug resistance 1.

Citation: Giroux P, Kyle PB, Tan C, Edwards JD, Nowicki MJ, Liu H. Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance. World J Gastrointest Pathophysiol 2022; 13(3): 73-84
URL: https://www.wjgnet.com/2150-5330/full/v13/i3/73.htm
DOI: https://dx.doi.org/10.4291/wjgp.v13.i3.73