Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance

Table 2 Liver panel, bilirubin, blood urea nitrogen and creatinine

	Sham		BDL
	Pre-surgery	Post-surgery	Pre-surgery	Post-surgery
Tot protein	6.63 ± 0.27	6.53 ± 0.35	6.53 ± 0.42	6.75 ± 0.23
Albumin	4.08 ± 0.17	3.85 ± 0.34	4.05 ± 0.14	3.40 ± 0.13a
ALP	137.8 ± 19.78	122.3 ± 14.45	141.5 ± 12.74	467.2 ± 59.79a
Bilirubin, D	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0.01	6.62 ± 1.72a
Bilirubin, T	0.04 ± 0.02	0.06 ± 0.01	0.05 ± 0.02	11.67 ± 1.82a
ALT	36.00 ± 12.02	57.00 ± 10.47	24.83 ± 8.28	191.8 ± 42.29a
AST	71.83 ± 11.53	82.17 ± 4.92	64.17 ± 7.57	525.8 ± 107.11a
BUN	17.54 ± 2.71	16.17 ± 3.13	18.23 ± 4.21	19.00 ± 5.57
Creatinine	0.27 ± 0.03	0.25 ± 0.02	0.29 ± 0.03	0.28 ± 0.04

^aP < 0.05 vs pre-surgery.

Values are expressed as means ± SD of 6 rats per group. BDL: Bile duct ligation; ALT: Alanine transaminase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; BUN: Blood urea nitrogen.