Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance

doi:10.4291/wjgp.v13.i3.73

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May 22, 2022 (publication date) through Sep 1, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. May 22, 2022; 13(3): 73-84
Published online May 22, 2022. doi: 10.4291/wjgp.v13.i3.73

Table 1 Real time polymerase chain reaction primer sequences, product size and positive controls

Target gene	Primer sequences (5’-3’)	Size (bp)	Positive control
MDR1	ATCAACTCGCAAAAGCATCC (F)	116	Kidney
MDR1	AATTCAACTTCAGGATCCGC (R)	116	Kidney
OATP1A4	TGTGATGACCTGTGATAATTTTCCA (F)	81	Liver
OATP1A4	TTCTCCACATATAGTTGGTGCTGAA (R)	81	Liver
OATP4C1	TCAAGCTGGCAAAACTTCCC (F)	239	Kidney
OATP4C1	CCGCAAAGCTCGATGTCAAT (R)	239	Kidney
GAPDH	AAGATGGTGAAGGTCGGTGT (F)	98	Liver
GAPDH	GTTGATGGCAACAATGTCCACT (R)	98	Liver

OATP: Organic anion transporting polypeptides; MDR1: Multidrug resistance 1; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.

Citation: Giroux P, Kyle PB, Tan C, Edwards JD, Nowicki MJ, Liu H. Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance. World J Gastrointest Pathophysiol 2022; 13(3): 73-84
URL: https://www.wjgnet.com/2150-5330/full/v13/i3/73.htm
DOI: https://dx.doi.org/10.4291/wjgp.v13.i3.73