Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

Figure 3 A heat map showing gene dysregulation in mild moderate and severe acute pancreatitis patients compared to healthy controls. Hierarchical cluster of all the genes across patient severities are shown. Red colour represents upregulated genes, green is downregulated and black is unchanged. Chemokine receptor 8 (CCR8) was shown to increase with severity and so were GAPDH, NOD1, TRL 1, TICAM 1, TBX21, and CASP1, which are associated with CCR8 expression. GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; NOD1: Nucleotide-binding oligomerization domain-containing protein 1; TRL 1: Toll like receptor 1; TICAM 1: Toll Like Receptor Adaptor Molecule 1; TBX21: T-Box Transcription Factor 21; CASP1: Caspase 1; apoptosis-related cysteine peptidase; CCR8: Chemokine receptor 8; MAP: Mild acute pancreatitis; MSAP: Moderately severe acute pancreatitis; SAP: Severe acute pancreatitis.