Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

Figure 2 IL-6 secretion levels acquired using the MILLIPLEX^® MAP Human Th17 Magnetic Bead Panel kit. Analysis was done on 23 patients sampled on Day 3 and Day 7 and 6 healthy controls were included. The concentration of interleukin (IL)-6 was highest in the SAP group 50 ± 50 pg/mL and 65 ± 61 pg/ml on D3 (n = 2) and D7 (n = 5) respectively. The MAP group IL-6 levels were 13 ± 8 pg/mL (n = 7) and MSAP 20 ± 13 pg/mL groups (n = 4) on D3. Significant differences were observed between the healthy controls (n = 6) and MSAP at D3 (n = 4) with P = 0.014 and P = 0.013 respectively. A Dunn’s multiple comparison test was used as a post hoc to adjust P values. D: Day of the specific severity group; n: number; MAP: Mild acute pancreatitis; MSAP: Moderately severe acute pancreatitis; SAP: Severe acute pancreatitis; IL-6: Interleukin-6.