Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor

Table 3 Colorectal cancer hereditary risk factors

Factor	CRC hereditary, yes (n: 13)	CRC hereditary, no (n: 27)	OR (95%CI)	P value
Age	50.69 ± 14.99	59.74 ± 11.68		0.043
< 50	8 (61.54)	6 (22.22)	5.60 (1.33-23.62)	0.031
> 50	5 (38.46)	21 (77.78)
Gender			0.69 (0.18-2.59)	0.826
Male	6 (46.15)	15 (55.56)
Female	7 (53.85)	12 (44.44)
Location			-	0.595
Caecum	1 (7.69)	1 (3.70)
Ascending colon	2 (15.38)	4 (14.81)
Transverse colon	2 (15.38)	2 (7.41)
Descending colon	0 (0.00)	1 (3.70)
Sigmoid	3 (23.08)	7 (25.93)
Rectum	5 (38.46)	12 (44.44)
Proximity			1.79 (0.44-7.32)	0.476
Proximal colon	5 (38.46)	7 (25.93)
Distal colon	8 (61.54)	20 (74.07)
Staging			-	0.020
A	0 (0.00)	7 (25.93)
B	4 (30.77)	10 (37.04)
C	7 (54.85)	9 (33.33)
D	2 (15.38)	1 (3.70)
Group staging			3.83 (0.93-15.72)	0.116
C-D	9 (69.23)	10 (37.04)
A-B	4 (30.77)	17 (62.96)
Family history			9.20 (1.97-42.97)	0.008
Yes	8 (61.54)	4 (14.81)
No	5 (38.46)	23 (85.19)
Differentiation1
Poor	4 (30.77)	3 (11.54)	2.52 (0.46-13.80)	0.287
Intermediate	0 (0.00)	6 (23.08)	-	0.999
Well	9 (69.23)	17 (65.38)

¹Loss of differentiation data in one sample. CRC: Colorectal cancer; OR: Odds ratio; CI: Confidence interval.