Cholangiocarcinoma and liver transplantation: What we know so far?

Table 4 Unique microRNAs that were identified to promote the pathogenesis of cholangiocarcinoma

miRNAs	Target gene	Correlation with CCA tumorigenesis	Upregulated/downregulated	Ref.
miR-26a	GSK-3b	Tumor growth	Upregulated	Zhang et al[127], 2012
miR-24	MEN1(11q13)	Tumor suppressor gene	Upregulated	Ehrlich et al[128], 2017
miR-29b	MCL-1	Tumor suppressor gene	Downregulated	Stutes et al[129], 2007
let-7a	NF2	Tumor suppressor gene	Upregulated
miR-148a	DNMT-1	Regulate methyltransferase	Downregulated	Braconi et al[130], 2010
miR-124	SMYD3	Migration and invasion of CCA cells	Downregulated	Zeng et al[131], 2012
miR-21	PTEN	Tumor suppressor gene	Upregulated	Meng et al[132], 2006
miR-152	DNMT-1	Regulate methyltransferase	Downregulated	Braconi et al[130], 2010
miR-200b	PTPN12	Tumor suppressor gene	Upregulated	Meng et al[132], 2006
miR-429	CDH-6	Tumor suppressor gene	Upregulated	Goeppert et al[133], 2016
miR-122, miR-145, miR-200c, miR-221, and miR-222	Multiple	Associated with tumorigenesis of ICCA	Downregulated	Karakatsanis et al[134], 2013
miR-21, miR-31, and miR-223	Multiple	No association with clinic-pathological parameters of CCA	Upregulated
miR-370	MAP3K8	Tumor suppressor gene	Downregulated	Stutes et al[129], 2007
miR-141	CLOCK	Tumor suppressor gene	Upregulated	Meng et al[132], 2006
miR-214	Twist	Oncogene	Downregulated	Li et al[135], 2012

CCA: Cholangiocarcinoma; CXCR4: C-X-C chemokine receptor type 4; MAP3K8: Mitogen-Activated Protein Kinase Kinase Kinase 8; PTEN: Phosphatase and TENsin homolog deleted on chromosome 10; GSK-3b: Glycogen synthase kinase 3 beta; SMYD3: SET and MYN-domain containing 3; MCL-1: myeloid cell leukemia-1; NF2: Neurofibromatosis type 2.