Influence of anastomoses on intestine ischemia and cefuroxime concentrations: Evaluated in the ileum and colon in a porcine model

Table 5 Pharmacokinetic parameters for plasma and for both non-anastomosis and anastomosis ileum and colon

Compartment	Non-anastomosis	Anastomosis	P value
Plasma AUC (min μg/mL)	4849 (4003; 5786)a	-	-
Ileum AUC (min μg/mL)	3678 (2786; 4570)	3327 (2436; 4219)	0.28
Colon AUC (min μg/mL)	4219 (3327; 5110)	3542 (2622; 4462)	0.61
Plasma Cmax (μg/mL)	147 (131; 163)b	-	-
Ileum Cmax (μg/mL)	51 (35; 66)	46 (30; 62)	0.65
Colon Cmax (μg/mL)	58 (42; 74)	39 (22; 56)	0.08
Plasma Tmax (min)	10 (5; 15)b	-	-
Ileum Tmax (min)	28 (23; 32)	28 (23; 32)	1.00
Colon Tmax (min)	25 (20; 30)	33 (27; 38)	0.03
Plasma T1/2 (min)	58 (44; 73)	-	-
Ileum T1/2 (min)	54 (39; 68)	52 (37; 66)	0.70
Colon T1/2 (min)	53 (38; 67)	66 (52; 81)	0.02
Ileum AUCtissue/AUCplasma	0.74 (0.57; 0.91)	0.68 (0.50; 0.85)	0.56
Colon AUCtissue/AUCplasma	0.90 (73; 1.07)	0.72 (0.53; 0.90)	0.12

AUC, Cmax, Tmax, and T1/2 are given as means (95% confidence interval).

^aP = 0.01 for comparison with all compartments but not non-anastomosis colon.

^bP < 0.01 for comparison with all compartments.

AUC: Area under the concentration–time curve from; C_max: Peak drug concentration; T_max: Time to C_max; T_1/2: Half-life; AUC_tissue/AUC_plasma: Area under the concentration-time curve ratio of tissue/plasma.