P2X7 receptor antagonist recovers ileum myenteric neurons after experimental ulcerative colitis

Figure 11 Frequency distribution in cell profiles of neuronal immunoreactivity of neurons among neurons of the rat ileum myenteric plexus in the sham, 2,4,6-trinitrobenzene sulfonic acid and brilliant blue G groups. A: Neuronal nitric oxide synthase (nNOS); B: Choline acetyltransferase (ChAT); C: HuC/D. The size of nNOS-immunoreactive neurons ranged from 50-1050 μm². The size of ChAT-immunoreactive neurons ranged from 50-950 μm². The size of HuC/D neurons ranged from 50-850 μm². The cell perikaryal profile areas of 100 neurons positive for nNOS, ChAT and HuC/D cells from each animal were obtained in the sham (n = 5), 2,4,6-trinitrobenzene sulfonic acid (n = 5) and brilliant blue G groups (n = 5). nNOS: Neuronal nitric oxide synthase; ChAT: Choline acetyltransferase; TNBS: 2,4,6-trinitrobenzene sulfonic acid; BBG: Brilliant blue G.