Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification

Figure 2 Usefulness of Faecalibacterium prausnitzii, its phylogroups (PHGI and PHGII) and their index in conjunction to Escherichia coli to discriminate inflammatory bowel disease with colon inflammation and colorectal cancer by pooling all biopsy samples together (A) and by location of sampling (B). For the best biomarker, results depicted by activity status of the patients are shown in the right panels. Best area under the receiver operating characteristic curve (AUC) values for each comparison are shown. •: AUC not calculated (comparisons with one empty group of subjects). E1: Ulcerative proctitis; E2: Distal UC; E3: Extensive UC or ulcerative pancolitis; C-CD: Colonic-CD; IC-CD: Ileocolonic-CD; FP: Faecalibacterium prausnitzii; UC: Ulcerative colitis; CRC: Colorectal cancer; CD: Crohn’s disease.