Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings

Figure 2 Programmed cell death protein 1 inhibitor-associated colitis. A: This colon biopsy reveals lamina propria expansion by lymphoplasmacytic infiltrate. Crypt distortion, crypt abscess, and cryptitis are prominent in the mucosa. In the stroma, a significantly increased eosinophilic infiltrate is observed; B: In another case of immune checkpoint inhibitors-related colitic mucosa, a subluminal collagen band thickening is prominent as observed in collagenous colitis. (Hematoxylin and eosin original magnification × 20, a scale bar represents 500 µm).