Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis

Figure 5 Suppression of somatostatin with chronic infusion of pentagastrin in the sheep model. A: Infusion of pentagastrin for 4 h in the sheep stimulates the release of somatostatin followed by a gradual decrease in concentration. The stimulatory effect of pentagastrin on somatostatin is greater with thioperamide infusion; B: Somatostatin integrated plasma response (IPR, pmol/mL per minute) showing a significant increase in pentagastrin stimulated somatostatin with thioperamide treatment. PG: pentagastrin; THIO: thioperamide. Data shown as mean + SEM, ^aP < 0.05 versus PG, n = 6 for PG infusion, n = 3 for THIO + PG infusion. The IPR was calculated as the area under the somatostatin time curve as follows: IPR = DS₀ - DS₁× (t₁ - t₂) + …. DS_n-DS_n-1× (t_n - t_n-1); DS: plasma somatostatin-basal somatostatin concentrations; t: time of infusion; Subscripts 0, 1, 2…n: times at which samples were collected.