Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis

Figure 3 Hypergastrinemia induced by Helicobacter felis infection is resolved with thioperamide treatment. A: Quantitative RT-PCR was performed on RNA isolated from the antral mucosa. Shown is the ratio of gastrin to HPRT mRNA in PBS, H. felis (HF), thioperamide (THIO) and THIO plus HF treated mice; B: Changes in plasma gastrin were determined by radioimmunoassay. Data are the mean + SEM for n = 8 mice; ^aP < 0.05 vs PBS control mice; ^bP < 0.05 vs THIO treated mice.