Immune-mediated bile duct injury: The case of primary biliary cirrhosis

Table 2 Features of spontaneous and induced murine primary biliary cirrhosis models resembling data in the human condition

	Mouse model	Adaptive immunity	Innate immunity
Spontaneous	Ae2(a.b)-deficient	AMA	--
		Lymphocytic CD8+ infiltrates
		Decreased T regulatory cells
		PBC-like liver lesions
	dnTGFbRII	AMA	NKT cells worsen liver injury
		Deficient T reg function
	IL2Ra-/-	AMA	--
		Portal tract CD4+ and CD8+ cells
	NOD.c3c4	Lymphocytic infiltrate	--
		AMA, ANA
Induced	N. aromaticivorans on NOD 1101	AMA	NKT cells are required
		PBC-like liver lesions
		Disease transfer by T cells
	Xenobiotic on C57BL/6	Lymphocytic CD8+ infiltrate	--
		AMA
		PBC-like liver lesions

AMA: antimitochondrial autoantibodies; ANA: antinuclear antibodies; NOD: non obese diabetic; PBC: primary biliary cirrhosis models.