Immune-mediated bile duct injury: The case of primary biliary cirrhosis

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Oct 15, 2010 (publication date) through Jul 24, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Oct 15, 2010; 1(4): 118-128
Published online Oct 15, 2010. doi: 10.4291/wjgp.v1.i4.118

Table 1 Hints towards an innate immunity involvement in primary biliary cirrhosis

	Peculiarity
Monocytes	Increase in absolute number
Monocytes	Increase in pro-inflammatory cytokines upon infectious challenge
Elevated IgM	B cell response to bacterial stimuli
NKT cells	Increased NKT cells in PBC peripheral blood and liver
NKT cells	Increased NKT cytotoxic activity
Liver histology	Focal duct obliteration with granuloma formation

PBC: primary biliary cirrhosis models.

Citation: Selmi C, Affronti A, Ferrari L, Invernizzi P. Immune-mediated bile duct injury: The case of primary biliary cirrhosis. World J Gastrointest Pathophysiol 2010; 1(4): 118-128
URL: https://www.wjgnet.com/2150-5330/full/v1/i4/118.htm
DOI: https://dx.doi.org/10.4291/wjgp.v1.i4.118