Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome

Table 1 Rome III criteria

Recurrent abdominal pain or discomfort for at least 3 d per month in the last 3 mo associated with two or more of the following

Improvement with defecation

Onset associated with a change in frequency of stool

Onset associated with a change in form (appearance) of stool