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©2010 Baishideng.
World J Gastrointest Pathophysiol. Jun 15, 2010; 1(2): 38-49
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.38
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.38
Expression level | Agonist effect | Antagonist effect | In vitro/in vivo model | Known or potential signaling mechanism | |
Histidine decarboxylase (HDC) | ↑↑ | ↓↓ CCA growth | Both | Inhibits histamine synthesis | |
Monoamine oxidase-B (MAOB) | ↓↓ | Unknown | Unknown | In vitro | Unknown |
Histamine | ↑↑ secretion by CCA | ↑↑ CCA growth | ↓↓ CCA growth | Both | ↑↓ VEGF expression |
H1HR | ↑↑ | ↑ CCA growth | ↓↓ CCA growth | In vitro | Ca2+-mediated signaling |
H2HR | ↑↑ | ↔ | ↔ | Both | Unknown |
H3HR | ↑↑ | ↓↓ CCA growth | Both | PKCa-dependent signaling | |
H4HR | ↑↑ | ↓↓ CCA growth | In vitro | Integrin-dependent decreased invasion |
- Citation: Onori P, Gaudio E, Franchitto A, Alpini G, Francis H. Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes. World J Gastrointest Pathophysiol 2010; 1(2): 38-49
- URL: https://www.wjgnet.com/2150-5330/full/v1/i2/38.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v1.i2.38