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Copyright ©2010 Baishideng.
World J Gastrointest Pathophysiol. Jun 15, 2010; 1(2): 38-49
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.38
Table 1 Effects of histamine and histamine receptors on cholangiocarcinomagrowth
Expression levelAgonist effectAntagonist effectIn vitro/in vivo modelKnown or potential signaling mechanism
Histidine decarboxylase (HDC)↑↑↓↓ CCA growthBothInhibits histamine synthesis
Monoamine oxidase-B (MAOB)↓↓UnknownUnknownIn vitroUnknown
Histamine↑↑ secretion by CCA↑↑ CCA growth↓↓ CCA growthBoth↑↓ VEGF expression
H1HR↑↑↑ CCA growth↓↓ CCA growthIn vitroCa2+-mediated signaling
H2HR↑↑BothUnknown
H3HR↑↑↓↓ CCA growthBothPKCa-dependent signaling
H4HR↑↑↓↓ CCA growthIn vitroIntegrin-dependent decreased invasion