Correlation of magnetic resonance signal characteristics and perfusion parameters assessed by volume perfusion computed tomography in hepatocellular carcinoma: Impact on lesion characterization

Table 3 T1 and T2-signal characteristics, wash-in/wash-out kinetics and growth pattern in relation to histology and volume perfusion computed tomography parameters in n = 36 lesions

	ALP	PVP	HPI	G1 (n = 15)	G2 (n = 18)	G3 (n = 3)
T2-Signal characteristics
Hyperintense (n = 21)	47.3 ± 18.7	3.0 ± 2.7	92.5 ± 7.1	8	13	0
Isointense (n = 14)	51.2 ± 17.3	1.1 ± 1.7	97.3 ± 4.4	6	5	3
Hypointense (n = 1)	80.7	0	100	1	0	0
P value for student t test P value hyperintens vs isointense	1P = 0.20 P = 0.54	1P = 0.06 P = 0.02	1P = 0.07 P = 0.03	28.5 P = 0.08
T1-Signal characteristics
Hyperintense (n = 5)	59.7 ± 16.5	3.6 ± 2.6	92.8 ± 3.2	4	1	0
Isointense (n = 16)	46.5.0 ± 9.9	1.4 ± 2.2	96.2 ± 1.6	5	8	3
Hypointense (n = 15)	50.1 ± 25.0	2.5 ± 2.8	93.5 ± 1.7	6	9	0
P value for	1P = 0.44	1P = 0.25	1P = 0.44	28.1 2P = 0.09
Wash-in
Wash-in (n = 33)	50.7 ± 18.9	2.3 ± 2.6	94.3 ± 6.6	15	15	3
No wash-in (n = 3)	40.6 ± 12.0	0.6 ± 0.6	98.4 ± 2.1	0	3	0
P value for	3P = 0.37	3P = 0.25	3P = 0.046	24.4 P = 0.11
Wash-out
Wash-out (n = 25)	49.7 ± 18.2	2.1 ± 2.3	94.8 ± 5.8	6	16	3
No wash-out (n = 11)	50.2 ± 20.2	2.1 ± 3.2	94.4 ± 8.2	9	2	0
P value for	3P = 0.94	3P = 0.98	3P = 0.89	211.6 P = 0.005
Growth-pattern
Infiltrative (n = 5)	53.4 ± 21.0	1.0 ± 1.1	94.0 ± 6.8	2	3	0
Encapsulated (n = 31)	49.0 ± 18.6	2.4 ± 2.7	97.4 ± 3.7	12	16	3
P value for	3P = 0.67	3P = 0.07	3P = 0.13	21 P = 0.60

¹Analysis of variance;

²χ²;

³t test. BF: Blood flow; BV: Blood volume; ALP: Arterial liver perfusion; PVP: Portal venous perfusion; HPI: Hepatic perfusion index.