Brainstem tegmental lesions in neonates with hypoxic-ischemic encephalopathy: Magnetic resonance diagnosis and clinical outcome

Figure 3 Brainstem tegmental lesions of the central tegmental tracts. A 1-year-old infant shows generalized hypotonia, macrocephaly and psycho-motor developmental delay, without a history of hypoxic-ischemic encephalopathy or adverse perinatal events. A genetic syndrome is suspected and is currently not known. MR images show isolated T2 hyperintense (white arrows in B, E, and H) and T1 hypointense (white arrows in C, F, and I) bilateral and symmetric tegmental lesions of the pons and caudal midbrain. Faint T2 hyperintense signal is observed at the rostral medulla oblongata. Columnar shape of alterations is demonstrated in coronal T2 weighted images (J). No signal alterations are detected at the supratentorial level (J). Sagittal views of the brainstem (A, D, and G) are used for reference of axial images. MR: Magnetic resonance.