Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancer

Table 1 Clinical reports investigating the relationship between ¹⁸F-fluorodeoxyglucose accumulation and KRAS mutations

Ref.	Cancer type	Sample size	Parameters related to KRAS mutations	Sensitivity (%)	Specificity (%)	Accuracy (%)
Kawada et al[22]	CRC	51	SUVmax	74.0	75.0	75.0
			TLR	70.0	71.0	71.0
Chen et al[23]	CRC	121	SUVmax	52.4	71.7	70.0
	CRC	121	TW40%	53.2	67.6	62.0
	RC	49	TW40%	80.0	79.1	71.4
Miles et al[24]	CRC	33	Dicision tree with SUVmax, MPP and BF	82.4	100.0	90.1
Lee et al[25]	CRC	132	SUVmax	60.0	50.3	54.0
			SUVpeak	73.3	60.5	67.8
Caicedo et al[29]	NSCLC	102	SUVmean	78.6	62.2	66.7
Kawada et al[26]	mCRC	42	SUVmax	68.0	74.0	71.4

SUV: Standardized uptake value; TLR: Tumor-to-liver SUV ratio; TW40%: A 40% threshold level of SUVmax for tumor width; MPP: Mean of positive pixels; BF: Blood flow; CRC: Colorectal cancer; RC: Rectal cancer; NSCLC: Non-small-cell lung cancer; mCRC: Metastatic CRC.