Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?

Table 4 Comparison of parameters of high resolution computed tomography scoring system and functional parameters within the 3 groups according to the predominant type of fibrosis

Parameters	Group F1Typical UIPn = 19Mean (95%CI)	Group F2Possible UIPn = 10Mean (95%CI)	Group F3NSIPn = 24Mean (95%CI)
Emphysema	7.05 (2.96-11.14)c	9.6 (3.33-15.86)e	23.08 (15.1-31.06)
TotExtILD	56.84 (43.18-70.49)d	39.6 (19.83-59.36)	28.16 (20.94-35.38)
RetNOS	18.68 (12.78-24.58)c	9.9 (5.51-14.28)	11.04 (7.48-14.6)
ExtGGOBx	18.05 (12.02-24.08)c	17.9 (2.84-32.95)e	3.66 (1.84-5.48)
GGO	7.36 (2.34-12.39)	8 (2.98-13.01)	13.45 (8.45-18.45)
HC	12.78 (7.65-17.92)da	3.8 (1.25-6.34)	-
Coarseness	10.73 (9.67-11.80)da	8.5 (7.22-9.77)f	4.87 (4.24-5.50)
RetNOS prop	32.44 (27.51-37.36)	30.08 (21.35-38.80)	42.63 (35.51- 49.76)
ExtGGOBx prop	30.86 (22.36-39.35)d	36.98 (21.53-52.42)f	11.24 (5.63-16.85)
ExtGGO prop	10.44 (4.07-16.81)d	19.97 (10.11-29.82)f	46.10 (36.95- 55.25)
HC prop	26.63 (16.13-37.13)d	12.95 (2.16-23.74)	-
FEV1	66.51 (41.27-91.75)	76.82 (27.32-126.32)	87.39 (70.19-104.58)
FEV1/FVC	81.04 (75.47-86.61)	84.83 (74.00-95.66)	74.98 (68.95-81.00)
PEF	82.80 (44.11-121.50)	85.86 (-55.76-227.49)	80.53 (61.05-100.01)
MMEF 75%-25%	73.90 (47.97-99.84)	75.76 (43.89-107.64)	65.02 (47.55- 82.50)
FVC	69.16 (55.02- 83.30)	74.38 (51.03-97.73)	85.66 (73.70-97.62)
TLC	54.77 (41.67-67.87)d	67.3 (52.53-82.06)	84.09 (75.99-92.18)
RV	54.69 (17.24-92.13)	71.3 (36.58-106.01)	87.80 (68.45-107.15)
RVTLC	89.92 (47.00-132.84)	97.89 (-64.43- 260.21)	101.06 (88.98-113.14)
DLCOsb	27.35 (19.85-34.85)ca	54.44 (27.51- 81.36)	47.73 (34.24-61.22)
SPAP (n = 12)	48.12 (32.49-63.75)	-	27.33 (10.42-44.24)

One - way ANOVA: Typical UIP vs possible UIP;

^aP≤ 0.05, ^bP≤ 0.001; Typical UIP vs NSIP;

^cP≤ 0.05,

^dP≤ 0.001; possible UIP vs NSIP;

^eP≤ 0.05,

^fP≤ 0.001. TotExtILD: Total extent of interstitial lung disease; RetNOS: Extent of reticular pattern not otherwise specified; ExtGGOBx: Extent of ground glass opacity with traction bronchiectasis; GGO: Extent of pure ground glass opacity; HC: Extent of honeycombing; Coarseness: Coarseness of fibrosis; FEV1: Forced expiratory volume in 1 s; FEV1/FVC: Ratio of forced expiratory volume in 1 s/forced vital capacity; PEF: Peak expiratory flow; MMEF: Maximum midexpiratory flow; FVC: Forced vital capacity; TLC: Total lung capacity; RV: Residual volume; DLCOsb: Single-breath diffusing capacity of the lungs for carbon monoxide; DLCOva: Diffusing capacity of the lungs for carbon monoxide corrected for alveolar volume.