Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?

Table 3 Parameters of high resolution computed tomography scoring system and functional pulmonary parameters in the groups according to the predominant type of emphysema

Parameters	Group E1Paraseptal emphyseman = 23Mean (95%CI)	Group E2Centrilobular emphyseman = 28Mean (95%CI)	Independent samplest testP value
Emphysema	6.3 (2.9-9.7)	21.82 (14.93-28.85)	< 0.001
TotExtILD	53.34 (41.05-65.63)	29.82 (22.09-37.55)	0.002
RetNOS	17.56 (12.45-22.67)	10.75 (7.67-13.82)	0.023
ExtGGOBx	16.73 (11.52-21.89)	6.14 (1.65-10.62)	0.002
GGO	7.86 (3.49-12.23)	12.5 (8.06-16.93)	0.136
HC	11.21 (6.76-15.67)	0.42 (-0.31-1.17)	< 0.001
Coarseness	10.34 (9.36-11.32)	5.42 (4.61-6.24)	< 0.001
RetNOS prop	32.62 (28.57-36.67)	40.51 (34.03-46.99)	0.039
ExtGGOBx prop	30.83 (23.71-37.95)	15.62 (8.76-22.48)	0.003
GGO prop	12.97 (6.64-19.31)	41.70 (32.72-50.67)	< 0.001
HC prop	23.87 (14.80-32.94)	2.14 (-1.56-5.82)	< 0.001
FEV1	72.05	83.81	0.382
FEV1/FVC	81.82	75.79	0.109
PEF	89.47	76.17	0.436
MMEF 75%-25%	78.87	62.07	0.184
FVC	72.64	82.21	0.256
TLC	58.54	80.98	0.002
RV	53.3	88.54	0.022
RVTLC	89.92	108.3	0.276
DLCOsb	32.75	47.64	0.067
DLCOva	55.22	71.51	0.293
eSPAP (n = 12)	48.12	35.25	0.324

TotExtILD: Total extent of interstitial lung disease; RetNOS: Extent of reticular pattern not otherwise specified; ExtGGOBx: Extent of ground glass opacity with traction bronchiectasis; GGO: Extent of pure ground glass opacity; HC: Extent of honeycombing; Coarseness: Coarseness of fibrosis; FEV1: Forced expiratory volume in 1 s; FEV1/FVC: Ratio of forced expiratory volume in 1 s/forced vital capacity; PEF: Peak expiratory flow; MMEF: Maximum midexpiratory flow; FVC: Forced vital capacity; TLC: Total lung capacity; RV: Residual volume; DLCOsb: Single-breath diffusing capacity of the lungs for carbon monoxide; DLCOva: Diffusing capacity of the lungs for carbon monoxide corrected for alveolar volume.