Imaging of Gaucher disease

Figure 14 Bone marrow improvement on enzyme replacement therapy. Type 1 GD male patient with N370S/N370S genotype who began enzyme replacement therapy (ERT) in October of 2007 shows relatively rapid improvement of the bone marrow infiltration. Initial coronal T1 WI of the femora (A) demonstrates diffuse low SI throughout the medullary cavity consistent with marked infiltration. Coronal T1 WI in 2009 (B) after only 2 years of treatment shows significant improvement in the infiltration manifest by decreased low SI in the medullary cavity. In 2011, coronal T1 WI (C) shows continued slight decrease in the amount of low SI in the bone marrow.