Imaging of Gaucher disease

Figure 13 Visceral improvement on enzyme replacement therapy. Female type 3 Gaucher disease patient who began enzyme replacement therapy (ERT) in 2007. Initial evaluation in 2007 before starting ERT shows that the spleen extends down to the iliac crest on the T2 WI coronal image (A). On the axial T2 WI (B) the left lobe of the liver extends across the midline posterior to the lateral aspect of the left rectus abdominus muscle and anterior to the stomach. At that time the liver volume measured 1702 cc and the spleen volume measured 769 cc. After 6 years on treatment, repeat imaging in 2013 reveals the inferior edge of the spleen is now above the iliac crest on the coronal T1 WI (C) and the left lobe of the liver now extends only slightly across the midline to end posterior to the medial aspect of the rectus abdominus muscle and the stomach is now lateral to the liver on the axial T2 WI (D). In 2013, the liver volume measured 1163 cc and the spleen volume measured368 cc.