Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome

Figure 4 Chest X-ray in patient with differentiation syndrome showed mild cardiomegaly and increased pulmonary vascular marking in both lungs with thickening of small fissure and minimal pleural effusion on the right side seen as obliteration of right costo-phrenic angle: These findings are similar to those of congestive heart failure with pulmonary edema. In contrast with congestive heart failure the time for the complete healing is long, and is similar to that of interstitial pneumonia or acute respiratory distress syndrome. References: Institute of Radiology, Department of Clinical and Biological Sciences of University of Turin, AOU S.Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano, Torino, Italy.